ERK Oscillation-Dependent Gene Expression Patterns and Deregulation by Stress Response

ERK Oscillation-Dependent Gene Expression Patterns and Deregulation by Stress Response

Studies were undertaken to determine whether extracellular signal regulated kinase (ERK) oscillations regulate a unique subset of genes in human keratinocytes and subsequently whether the p38 stress response inhibits ERK oscillations. A DNA microarray identified many genes that were unique to ERK oscillations, and network reconstruction predicted an important role for the mediator complex subun...

Patterns of mitochondrial gene expression in rapeseed leaves (Brassica napus L.) at early growth stage in response to drought stress

Drought stress adversely affects a plant’s growth and productivity. Wide ranges of molecular disorders could be caused by the production of reactive oxygen radicals. Plant cells have developed potential systems to prevent such damage by scavenging and reducing the reactive oxygen species (ROS). In this study, both the genotypes of oilseed rape-tolerant and sensitive to drought-were exposed to p...

Deregulation of GLUT1 and glycolytic gene expression by c-Myc

Cell response to ionising radiation analysed by gene expression patterns.

Following ionising radiation exposure of living cells several mechanisms are activated through gene modulations. The measurement of these modifications can be done with QT-PCR and, since about 10 years, microarray technique. The latter approach has the advantage to allow a global monitoring of the complex cellular responses to radiation-induced stress and has been proposed to be used for dose a...

The Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity

Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...